![]() ![]() Minor criterion 2: increased serum lactate dehydrogenase.Minor criterion 1: leukoerythroblastosis.Major criterion 3: demonstration of JAK2, CALR or MPL mutation OR other clonal marker OR no evidence of reactive marrow fibrosis.Major criterion 2: not meeting WHO criteria for other myeloproliferative neoplasms or myelodysplastic syndromes.Major criterion 1: megakaryocyte proliferation and atypia in the absence of reticulin fibrosis, accompanied by increased marrow cellularity, granulocytic proliferation and often decreased erythropoiesis. #DEFINE PATHOLOGICAL FATIGUE PLUS#
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